Thiopeptide Antibiotics: Retrospective and Recent Advances
AbstractThiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.
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Just-Baringo, X.; Albericio, F.; Álvarez, M. Thiopeptide Antibiotics: Retrospective and Recent Advances. Mar. Drugs 2014, 12, 317-351.
Just-Baringo X, Albericio F, Álvarez M. Thiopeptide Antibiotics: Retrospective and Recent Advances. Marine Drugs. 2014; 12(1):317-351.Chicago/Turabian Style
Just-Baringo, Xavier; Albericio, Fernando; Álvarez, Mercedes. 2014. "Thiopeptide Antibiotics: Retrospective and Recent Advances." Mar. Drugs 12, no. 1: 317-351.