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Mar. Drugs 2017, 15(10), 308; doi:10.3390/md15100308

Diversity and Antimicrobial Potential of Predatory Bacteria from the Peruvian Coastline

1
Institute for Insect Biotechnology, Justus Liebig University of Giessen, 5392 Giessen, Germany
2
Institute for Pharmaceutical Biology, University of Bonn, 3115 Bonn, Germany
3
Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, 13011 Trujillo, Peru
4
German Centre for Infection Research (DZIF) Partner Site Bonn/Cologne, Bonn 53115, Germany
5
Research Centre for Sustainable Development Uku Pacha, 13011 Uku Pacha, Peru
*
Author to whom correspondence should be addressed.
Received: 6 September 2017 / Revised: 25 September 2017 / Accepted: 9 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue Marine Antimicrobial Agents)
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Abstract

The microbiome of three different sites at the Peruvian Pacific coast was analyzed, revealing a lower bacterial biodiversity at Isla Foca than at Paracas and Manglares, with 89 bacterial genera identified, as compared to 195 and 173 genera, respectively. Only 47 of the bacterial genera identified were common to all three sites. In order to obtain promising strains for the putative production of novel antimicrobials, predatory bacteria were isolated from these sampling sites, using two different bait organisms. Even though the proportion of predatory bacteria was only around 0.5% in the here investigated environmental microbiomes, by this approach in total 138 bacterial strains were isolated as axenic culture. 25% of strains showed antibacterial activity, thereby nine revealed activity against clinically relevant methicillin resistant Staphylococcus aureus (MRSA) and three against enterohemorrhagic Escherichia coli (EHEC) strains. Phylogeny and physiological characteristics of the active strains were investigated. First insights into the chemical basis of the antibacterial activity indicated the biosynthetic production of the known compounds ariakemicin, kocurin, naphthyridinomycin, pumilacidins, resistomycin, and surfactin. However, most compounds remained elusive until now. Hence, the obtained results implicate that the microbiome present at the various habitats at the Peruvian coastline is a promising source for heterotrophic bacterial strains showing high potential for the biotechnological production of antibiotics. View Full-Text
Keywords: antibiotics; dereplication; microbiome; natural products; predatory bacteria antibiotics; dereplication; microbiome; natural products; predatory bacteria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Linares-Otoya, L.; Linares-Otoya, V.; Armas-Mantilla, L.; Blanco-Olano, C.; Crüsemann, M.; Ganoza-Yupanqui, M.L.; Campos-Florian, J.; König, G.M.; Schäberle, T.F. Diversity and Antimicrobial Potential of Predatory Bacteria from the Peruvian Coastline. Mar. Drugs 2017, 15, 308.

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