Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59
AbstractAnandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 μg/mL, respectively. View Full-Text
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Zhang, Y.-M.; Liu, B.-L.; Zheng, X.-H.; Huang, X.-J.; Li, H.-Y.; Zhang, Y.; Zhang, T.-T.; Sun, D.-Y.; Lin, B.-R.; Zhou, G.-X. Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59. Mar. Drugs 2017, 15, 355.
Zhang Y-M, Liu B-L, Zheng X-H, Huang X-J, Li H-Y, Zhang Y, Zhang T-T, Sun D-Y, Lin B-R, Zhou G-X. Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59. Marine Drugs. 2017; 15(11):355.Chicago/Turabian Style
Zhang, Yang-Mei; Liu, Bai-Lian; Zheng, Xin-Heng; Huang, Xiao-Jun; Li, Hong-Yu; Zhang, Ying; Zhang, Ting-Ting; Sun, Da-Yuan; Lin, Bi-Run; Zhou, Guang-Xiong. 2017. "Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59." Mar. Drugs 15, no. 11: 355.
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