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Mar. Drugs 2017, 15(11), 355; doi:10.3390/md15110355

Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59

1
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou 510632, China
2
Key Laboratory of New Technique for Plant Protection in Guangdong, Institute of Plant Protection, Guangdong Academy of Agricultural Sciences, Guangzhou 510632, China
Co-first author.
*
Author to whom correspondence should be addressed.
Academic Editor: Peer Jacobson
Received: 26 August 2017 / Revised: 1 November 2017 / Accepted: 2 November 2017 / Published: 10 November 2017
View Full-Text   |   Download PDF [1447 KB, uploaded 14 November 2017]   |  

Abstract

Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 μg/mL, respectively. View Full-Text
Keywords: Streptomyces anandii; anandins A and B; steroidal alkaloids; cytotoxicity Streptomyces anandii; anandins A and B; steroidal alkaloids; cytotoxicity
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MDPI and ACS Style

Zhang, Y.-M.; Liu, B.-L.; Zheng, X.-H.; Huang, X.-J.; Li, H.-Y.; Zhang, Y.; Zhang, T.-T.; Sun, D.-Y.; Lin, B.-R.; Zhou, G.-X. Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59. Mar. Drugs 2017, 15, 355.

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