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Mar. Drugs 2017, 15(4), 109; doi:10.3390/md15040109

An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.

1
Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan
2
Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, Japan
3
R & D Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo 104-8315, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Yoshihide Usami
Received: 1 March 2017 / Revised: 31 March 2017 / Accepted: 4 April 2017 / Published: 6 April 2017
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
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Abstract

Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells. View Full-Text
Keywords: marine myxobacterium; diterpene; NGF-enhancing activity; cytotoxicity; antibacterial activity marine myxobacterium; diterpene; NGF-enhancing activity; cytotoxicity; antibacterial activity
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Tomura, T.; Nagashima, S.; Yamazaki, S.; Iizuka, T.; Fudou, R.; Ojika, M. An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.. Mar. Drugs 2017, 15, 109.

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