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Int. J. Environ. Res. Public Health 2013, 10(8), 3233-3245; doi:10.3390/ijerph10083233
Article

Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams

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1 Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, China 2 Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang 110001, China 3 Department of Physiology, the University of Tennessee Health Science Center, Memphis, TN 38163, USA
* Author to whom correspondence should be addressed.
Received: 21 June 2013 / Revised: 24 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
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Abstract

The main object of the present study was to explore the effect on thyroidal proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia during pregnancy and lactation. In the present study, we established a maternal hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal thyroid iodine content and thyroid weight were measured. Expressions of thyroid-associated proteins were analyzed. The results showed that the mild ID diet increased thyroid weight, decreased thyroid iodine content and increased expressions of thyroid transcription factor 1, paired box gene 8 and Na+/I symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the mild ID group on GD19 and PN21. Taken together, our data indicates that during pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and increase the thyroidal DIO1 and DIO2 levels.
Keywords: mild iodine deficiency; hypothyroxinemia; gestation; lactation; thyroid mild iodine deficiency; hypothyroxinemia; gestation; lactation; thyroid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wei, W.; Wang, Y.; Dong, J.; Wang, Y.; Min, H.; Song, B.; Shan, Z.; Teng, W.; Xi, Q.; Chen, J. Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams. Int. J. Environ. Res. Public Health 2013, 10, 3233-3245.

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