Int. J. Environ. Res. Public Health 2014, 11(6), 5628-5639; doi:10.3390/ijerph110605628
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment
1
Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia
2
Department of Ecology and Environmentalistics, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia
3
Department of Informatics, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia
4
Specialized Hospital of St. Zoerardus Zobor, 949 88 Nitra, Slovakia
5
Department of Chemistry, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia
6
Institute of Biophysics, Informatics and Biostatistics, Slovak Medical University, 833 03 Bratislava, Slovakia
7
Department of Environmental Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
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These authors contributed equally to this work.
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Received: 28 March 2014 / Revised: 15 May 2014 / Accepted: 16 May 2014 / Published: 26 May 2014
(This article belongs to the Special Issue Environment and Health - Bridging South, North, East and West: Proceedings from the ISEE, ISES and ISIAQ Conference 2013)
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Abstract
Many toxic substances in the workplace can modify human health and quality of life and there is still insufficient data on respiratory outcomes in adults exposed to phthalates. The aim of this work was to assess in waste management workers from the Nitra region of Slovakia (n = 30) the extent of exposure to phthalates and health-related outcomes. Four urinary phthalate metabolites mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MnBP), monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were determined by high-performance liquid chromatography with mass spectrometry (HPLC-MS/MS). Urinary concentration of MEHP was positively associated with ratio of forced expiratory volume in 1 s to forced vital capacity % (FEV1/FVC) (r = 0.431; p = 0.018) and MiNP with fat free mass index (FFMI) (r = 0.439; p = 0.015). The strongest predictor of pulmonary function was the pack/year index as smoking history that predicted a decrease of pulmonary parameters, the FEV1/FVC, % of predicted values of peak expiratory flow (PEF % of PV) and FEV1 % of PV. Unexpectedly, urinary MEHP and MINP were positively associated with pulmonary function expressed as PEF % of PV and FEV1/FVC. We hypothesize that occupational exposure to phthalates estimated from urinary metabolites (MEHP, MiNP) can modify pulmonary function on top of lifestyle factors. View Full-Text
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kolena, B.; Petrovicova, I.; Pilka, T.; Pucherova, Z.; Munk, M.; Matula, B.; Vankova, V.; Petlus, P.; Jenisova, Z.; Rozova, Z.; Wimmerova, S.; Trnovec, T. Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment. Int. J. Environ. Res. Public Health 2014, 11, 5628-5639.
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