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Materials 2013, 6(9), 3755-3763; doi:10.3390/ma6093755

Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome

1
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
2
Institutes of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China
*
Author to whom correspondence should be addressed.
Received: 7 June 2013 / Revised: 29 July 2013 / Accepted: 30 August 2013 / Published: 3 September 2013
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [389 KB, uploaded 3 September 2013]   |  

Abstract

To ease the side effects triggered by cytosine arabinoside (Ara-C) for acute leukemia treatment, a novel magnetic targeting anti-tumor drug delivery system was constructed through bacterial magnetosomes (BMs) from Magnetospirillum magneticum AMB-1 combined with Ara-C by crosslinking of genipin (GP). The results showed that Ara-C could be bonded onto the membrane surface of BMs effectively through chemical crosslinking induced by dual hand reagents GP. The average diameters of BMs and Ara-C-coupled BMs (ABMs) were 42.0 ± 8.6 and 72.7 ± 6.0 nm respectively, and the zeta potentials (−38.1 ± 9.1) revealed that these systems were stable, confirming the stability of the system. The optimal encapsulation efficiency and drug loading were 89.05% ± 2.33% and 47.05% ± 0.64% respectively when crosslinking reaction lasted for 72 h. The system also presented long-term stability and release behaviors without initial burst release (Ara-C could be released 80% within three months). Our results indicate that BMs have great potential in biomedical and clinical fields as a novel anti-tumor drug carrier. View Full-Text
Keywords: cytosine arabinoside; magnetosome; genipin; drug release cytosine arabinoside; magnetosome; genipin; drug release
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Deng, Q.; Liu, Y.; Wang, S.; Xie, M.; Wu, S.; Chen, A.; Wu, W. Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome. Materials 2013, 6, 3755-3763.

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