Involvement of Autophagy in Coronavirus Replication
AbstractCoronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3) in coronavirus replication. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Maier, H.J.; Britton, P. Involvement of Autophagy in Coronavirus Replication. Viruses 2012, 4, 3440-3451.
Maier HJ, Britton P. Involvement of Autophagy in Coronavirus Replication. Viruses. 2012; 4(12):3440-3451.Chicago/Turabian Style
Maier, Helena J.; Britton, Paul. 2012. "Involvement of Autophagy in Coronavirus Replication." Viruses 4, no. 12: 3440-3451.