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Viruses 2012, 4(5), 725-733; doi:10.3390/v4050725

Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells

1
Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA
2
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA
*
Author to whom correspondence should be addressed.
Received: 29 March 2012 / Revised: 18 April 2012 / Accepted: 24 April 2012 / Published: 2 May 2012
(This article belongs to the Special Issue Animal Arteriviruses and Coronaviruses)
View Full-Text   |   Download PDF [185 KB, 12 May 2015; original version 12 May 2015]

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.
Keywords: PRRSV; type I interferon; post-transcriptional regulation; translational control PRRSV; type I interferon; post-transcriptional regulation; translational control
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, X.; Christopher-Hennings, J. Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells. Viruses 2012, 4, 725-733.

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