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Viruses 2012, 4(9), 1509-1514; doi:10.3390/v4091509

Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?

1
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
2
Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Received: 13 August 2012 / Revised: 5 September 2012 / Accepted: 6 September 2012 / Published: 11 September 2012
(This article belongs to the Special Issue Modulation of Apoptosis by Viral Infection)
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Abstract

Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV. View Full-Text
Keywords: varicella zoster virus; apoptosis varicella zoster virus; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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James, S.F.; Mahalingam, R.; Gilden, D. Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? Viruses 2012, 4, 1509-1514.

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