Next Article in Journal
A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
Previous Article in Journal
San Martín, C., Correction: Latest Insights on Adenovirus Structure and Assembly. Viruses 2012, 4, 847-877.
Previous Article in Special Issue
Human Cytomegalovirus Encoded Homologs of Cytokines, Chemokines and their Receptors: Roles in Immunomodulation
Article Menu

Export Article

Open AccessReview
Viruses 2013, 5(1), 1-14; doi:10.3390/v5010001

Molecular Mechanisms of HIV Immune Evasion of the Innate Immune Response in Myeloid Cells

1
Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
2
Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA
3
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
4
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
5
Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Received: 7 November 2012 / Revised: 19 December 2012 / Accepted: 19 December 2012 / Published: 21 December 2012
(This article belongs to the Special Issue Immune Evasion)
View Full-Text   |   Download PDF [352 KB, uploaded 12 May 2015]   |  

Abstract

The expression of intrinsic antiviral factors by myeloid cells is a recently recognized mechanism of restricting lentiviral replication. Viruses that enter these cells must develop strategies to evade cellular antiviral factors to establish a productive infection. By studying the cellular targets of virally encoded proteins that are necessary to infect myeloid cells, a better understanding of cellular intrinsic antiviral strategies has now been achieved. Recent findings have provided insight into how the lentiviral accessory proteins, Vpx, Vpr and Vif counteract antiviral factors found in myeloid cells including SAMHD1, APOBEC3G, APOBEC3A, UNG2 and uracil. Here we review our current understanding of the molecular basis of how cellular antiviral factors function and the viral countermeasures that antagonize them to promote viral transmission and spread. View Full-Text
Keywords: HIV; immune evasion; Vpr; Ung2; myeloid HIV; immune evasion; Vpr; Ung2; myeloid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mashiba, M.; Collins, K.L. Molecular Mechanisms of HIV Immune Evasion of the Innate Immune Response in Myeloid Cells. Viruses 2013, 5, 1-14.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top