Next Article in Journal
Arenavirus Variations Due to Host-Specific Adaptation
Next Article in Special Issue
Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data
Previous Article in Journal
Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
Previous Article in Special Issue
Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
Article Menu

Export Article

Open AccessReview
Viruses 2013, 5(1), 226-240; doi:10.3390/v5010226

Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Received: 5 December 2012 / Revised: 23 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013
(This article belongs to the Special Issue Recent Progress in EBV Research)
View Full-Text   |   Download PDF [260 KB, uploaded 12 May 2015]   |  

Abstract

Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV. View Full-Text
Keywords: Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Smith, D.W.; Sugden, B. Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus. Viruses 2013, 5, 226-240.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top