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Viruses 2013, 5(2), 568-576; doi:10.3390/v5020568

Identifying the Viral Genes Encoding Envelope Glycoproteins for Differentiation of Cyprinid herpesvirus 3 Isolates

1
Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, Republic of Korea
2
Korea Ocean Research and Development Institute, Ansan, 426-744, Republic of Korea
3
Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Laboratoire de Génétique et Pathologie (LGP), Avenue de Mus de Loup, 17390 La Tremblade, France
*
Author to whom correspondence should be addressed.
Received: 3 January 2013 / Revised: 23 January 2013 / Accepted: 25 January 2013 / Published: 31 January 2013
(This article belongs to the Section Animal Viruses)
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Abstract

Cyprinid herpes virus 3 (CyHV-3) diseases have been reported around the world and are associated with high mortalities of koi (Cyprinus carpio). Although little work has been conducted on the molecular analysis of this virus, glycoprotein genes identified in the present study seem to be valuable targets for genetic comparison of this virus. Three envelope glycoprotein genes (ORF25, 65 and 116) of the CyHV-3 isolates from the USA, Israel, Japan and Korea were compared, and interestingly, sequence insertions or deletions were observed in these target regions. In addition, polymorphisms were presented in microsatellite zones from two glycoprotein genes (ORF65 and 116). In phylogenetic tree analysis, the Korean isolate was remarkably distinguished from USA, Israel, Japan isolates. These findings may be suitable for many applications including isolates differentiation and phylogeny studies. View Full-Text
Keywords: Cyprinid herpes virus 3; glycoprotein gene; Koi herpesvirus; microsatellite; polymorphism; phylogenetic tree Cyprinid herpes virus 3; glycoprotein gene; Koi herpesvirus; microsatellite; polymorphism; phylogenetic tree
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Han, J.E.; Kim, J.H.; Renault, T.; Jr., C.C.; Shin, S.P.; Jun, J.W.; Park, S.C. Identifying the Viral Genes Encoding Envelope Glycoproteins for Differentiation of Cyprinid herpesvirus 3 Isolates. Viruses 2013, 5, 568-576.

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