Viruses 2013, 5(8), 1948-1963; doi:10.3390/v5081948
Immunization against Small Ruminant Lentiviruses
Institute of Agrobiotechnology, CSIC-UPNA-Government of Navarra, Ctra. Mutilva Baja s/n, Navarra 31192, Spain
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Received: 14 June 2013 / Revised: 24 July 2013 / Accepted: 25 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Small Ruminant Lentiviruses)
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Abstract
Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies involve inactivated whole virus, subunit vaccines, DNA encoding viral proteins in the presence or absence of plasmids encoding immunological adjuvants and naturally or artificially attenuated viruses. In this review, we revisit, comprehensively, the immunization strategies against SRLV and analyze this double edged tool individually, as it may contribute to either controlling or enhancing virus replication and/or disease.Keywords:
small ruminant lentivirus; Maedi-Visna; immunization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
Reina, R.; Andrés, D.D.; Amorena, B. Immunization against Small Ruminant Lentiviruses. Viruses 2013, 5, 1948-1963.