Table of Contents
Viruses, Volume 9, Issue 4 (April 2017)
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Cover Story The Ty1 restriction factor p22 is encoded by internally initiated Ty1i RNA. It contains two [...] Read more. The Ty1 restriction factor p22 is encoded by internally initiated Ty1i RNA. It contains two functional initiation codons embedded within a distinct structural domain. Mutational analyses suggest that the p22 level decreases when this RNA domain is destabilized at the secondary or tertiary structural levels. Also, our data support the idea that Gag itself and possibly other cellular proteins interact with the AUG-containing structural motif of Ty1i RNA to modulate its stability and translation. Read full story