Next Article in Journal
Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis
Next Article in Special Issue
Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
Previous Article in Journal / Special Issue
Regulation of Telomere Homeostasis during Epstein-Barr virus Infection and Immortalization
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessFeature PaperReview
Viruses 2017, 9(8), 218; doi:10.3390/v9080218

The Telomeric Response to Viral Infection

The Wistar Institute, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Eric O. Freed and Benedikt B. Kaufer
Received: 9 July 2017 / Revised: 6 August 2017 / Accepted: 6 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Viruses and Telomeres)
View Full-Text   |   Download PDF [1662 KB, uploaded 9 August 2017]   |  

Abstract

The ends of linear genomes, whether viral or cellular, can elicit potent DNA damage and innate immune signals. DNA viruses entering the nucleus share many features with telomeres in their ability to either suppress or co-opt these pathways. Here, we review some of the common mechanisms that viruses and telomeres use to manage the DNA damage and innate immune response pathways. We highlight recent studies on the role of the telomere repeat-containing RNA (TERRA) in response to viral infection. We discuss how TERRA can be activated through a p53-response element embedded in a retrotransposon-like repeat found in human subtelomeres. We consider how TERRA can function as a danger signal when secreted in extracellular vesicles to induce inflammatory cytokines in neighboring cells. These findings suggest that TERRA may be part of the innate immune response to viral infection, and support the hypothesis that telomeres and viruses utilize common mechanisms to maintain genome integrity and regulate innate immunity. View Full-Text
Keywords: TERRA; ALT; telomere; virus; PML-NB; ND10; IFI16; p53; exosomes; innate immunity TERRA; ALT; telomere; virus; PML-NB; ND10; IFI16; p53; exosomes; innate immunity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, Z.; Deng, Z.; Tutton, S.; Lieberman, P.M. The Telomeric Response to Viral Infection. Viruses 2017, 9, 218.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top