Next Article in Journal
Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus
Next Article in Special Issue
Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes
Previous Article in Journal
Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection
Previous Article in Special Issue
Epigenetic Alterations in Human Papillomavirus-Associated Cancers
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Viruses 2017, 9(9), 254; doi:10.3390/v9090254

Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy

Institute of Virology, Saarland University Medical Center, 66421 Homburg/Saar, Germany
Received: 25 August 2017 / Revised: 7 September 2017 / Accepted: 8 September 2017 / Published: 12 September 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
View Full-Text   |   Download PDF [1035 KB, uploaded 12 September 2017]   |  

Abstract

Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Recent studies have demonstrated that HPV-transformed cells actively promote chronic stromal inflammation and conspire with cells in the local microenvironment to promote carcinogenesis. This review highlights the complex interplay between HPV-infected cells and the local immune microenvironment during oncogenic HPV infection, persistence, and malignant progression, and discusses new prospects for diagnosis and immunotherapy of HPV-associated cancers. View Full-Text
Keywords: human papillomavirus; cervical cancer; skin cancer; epidermodysplasia verruciformis; immune evasion; chronic inflammation; IL-6; JAK-STAT3; immunotherapy; immunoscore human papillomavirus; cervical cancer; skin cancer; epidermodysplasia verruciformis; immune evasion; chronic inflammation; IL-6; JAK-STAT3; immunotherapy; immunoscore
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Smola, S. Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy. Viruses 2017, 9, 254.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top