Table of Contents
Pharmaceutics, Volume 10, Issue 2 (June 2018)
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Cover Story (view full-size image) Implants and intravaginal rings can be designed with a core surrounded by a rate-controlling [...] Read more. Implants and intravaginal rings can be designed with a core surrounded by a rate-controlling membrane. Multiple products utilize poly(ethylene-co-vinyl acetate) (EVA) as the membrane polymer. EVA-based dosage formulations rely on polymer crystallinity changes to modulate the drug diffusion rates. This has proven effective in several commercial products; however, it presents challenges in ensuring consistent lot-to-lot polymer crystallinity. Hydrophilic polyurethanes swell when immersed in water dictated by their chemistry. Measured drug release rates correlate with the extent of polymer swelling. Tuning the water-swelling properties of polyurethanes provides an opportunity to modulate the release rate, independent of drug solubility in the membrane polymer. View the paper here.