Table of Contents
Pharmaceutics, Volume 9, Issue 3 (September 2017)
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Cover Story (view full-size image) To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing [...] Read more. To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays, in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). The tip portions of MN completely dissolved in the rat skin within 5 min after application in vivo. After application of ALN(TIP)-MN in mice, the bioavailability of ALN was approximately 96 %. In addition, the decrease in growth plate was effectively suppressed by this efficient delivery of ALN in a rat model of osteoporosis. Furthermore, no skin irritation was observed after application of ALN(TIP)-MN. View the paper.