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Nutrients 2013, 5(5), 1488-1499; doi:10.3390/nu5051488

Interaction between Host Cells and Microbes in Chemotherapy-Induced Mucositis

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5001, Australia
Received: 28 February 2013 / Revised: 5 April 2013 / Accepted: 7 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Gut Microbiota and Gut Function)
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Abstract

Cancer patients receiving chemotherapy often develop mucositis as a direct result of their treatment. Recently, the intestinal microbiota has attracted significant attention in the investigation of the pathobiology of mucositis, with a number of studies investigating the effects of chemotherapeutic agents on the microbiota. With significant effects on the intestinal microbiota occurring following the administration of chemotherapy, there is now interest surrounding the downstream pathological effects that may be associated with the altered intestinal ecology. This review seeks to identify links between signalling pathways previously demonstrated to have a role in the development of mucositis, and the altered intestinal microbiota.
Keywords: intestine; microbiota; chemotherapy; mucositis; toll like receptors; mitogen activated protein kinase intestine; microbiota; chemotherapy; mucositis; toll like receptors; mitogen activated protein kinase
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stringer, A.M. Interaction between Host Cells and Microbes in Chemotherapy-Induced Mucositis. Nutrients 2013, 5, 1488-1499.

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