Table of Contents
Nutrients, Volume 9, Issue 12 (December 2017)
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Cover Story Sarcopenia, the age-related loss of muscle mass and function, is a syndrome with a dramatic impact [...] Read more. Sarcopenia, the age-related loss of muscle mass and function, is a syndrome with a dramatic impact on clinical outcomes of older individuals. Emerging evidence from animal and human studies allow to hypothesize the involvement of the gut microbiota in transducing the anabolic signals from diet to skeletal muscle cells, in a dynamic “gut-muscle axis”. Conversely, the age-related changes in gut microbiota composition can promote inflammation and decrease anabolic stimuli to the muscle, contributing to sarcopenia onset. Exercise and dietary intervention can partly counterbalance these phenomena, putting gut microbiota at the center of a putative, intriguing cross-road, representing a very interesting target for future therapies. View this paper