Next Article in Journal
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups
Previous Article in Journal
Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models
Previous Article in Special Issue
Vitamin D: Moving Forward to Address Emerging Science
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessFeature PaperReview
Nutrients 2017, 9(12), 1327; doi:10.3390/nu9121327

Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy

1
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
2
Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd, 3B01, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Received: 12 October 2017 / Revised: 26 November 2017 / Accepted: 28 November 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Dietary Supplements)
View Full-Text   |   Download PDF [874 KB, uploaded 8 December 2017]   |  

Abstract

Iron is particularly important in pregnancy and infancy to meet the high demands for hematopoiesis, growth and development. Much attention has been given to conditions of iron deficiency (ID) and iron deficient anemia (IDA) because of the high global prevalence estimated in these vulnerable life stages. Emerging and preliminary evidence demonstrates, however, a U-shaped risk at both low and high iron status for birth and infant adverse health outcomes including growth, preterm birth, gestational diabetes, gastrointestinal health, and neurodegenerative diseases during aging. Such evidence raises questions about the effects of high iron intakes through supplementation or food fortification during pregnancy and infancy in iron-replete individuals. This review examines the emerging as well as the current understanding of iron needs and homeostasis during pregnancy and infancy, uncertainties in ascertaining iron status in these populations, and issues surrounding U-shaped risk curves in iron-replete pregnant women and infants. Implications for research and policy are discussed relative to screening and supplementation in these vulnerable populations, especially in developed countries in which the majority of these populations are likely iron-replete. View Full-Text
Keywords: iron supplementation; iron-replete; pregnancy; infancy iron supplementation; iron-replete; pregnancy; infancy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Brannon, P.M.; Taylor, C.L. Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy. Nutrients 2017, 9, 1327.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top