Next Article in Journal
The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
Next Article in Special Issue
Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol?
Previous Article in Journal
Effects of the Mediterranean Diet before and after Weight Loss on Eating Behavioral Traits in Men with Metabolic Syndrome
Previous Article in Special Issue
Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Nutrients 2017, 9(3), 306; doi:10.3390/nu9030306

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

Laboratory of Cardiovascular Pharm-Ecology EA4278, Department of Sport Sciences, Faculty of Sciences, Avignon University, F-84000 Avignon, France
Unité Mixte de Recherche (UMR), Nutrition, Obesity and Risk of Thrombosis, Aix-Marseille University, F-13005 Marseille, France
Unité Mixte de Recherche (UMR), Markets, Organisations, Institutions, Stakeholder Strategies, F-34060 Montpellier, France
Centre de Coopération Internationale en Recherche Agronomique pour le Développement, F-34060 Montpellier, France
Centre International de Hautes Études Agronomiques Méditerranéennes, F-34060 Montpellier, France
Montpellier SupAgro, F-34060 Montpellier, France
Institut National de la Recherche Agronomique; Division of Nutrtition, Chemical Food Safety and Consumer Behaviour, F-75015 Paris, France
Institut National de la Santé et de la Recherche Médicale, F-75015 Paris, France
Authors to whom correspondence should be addressed.
Received: 15 February 2017 / Revised: 12 March 2017 / Accepted: 16 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue Precision Nutrition and Metabolic Syndrome Management)
View Full-Text   |   Download PDF [521 KB, uploaded 20 March 2017]   |  


Virgin olive oil (VOO) constitutes the main source of fat in the Mediterranean diet. VOO is rich in oleic acid, displaying health-promoting properties, but also contains minor bioactive components, especially phenolic compounds. Hydroxytyrosol (HT), the main polyphenol of olive oil, has been reported to be the most bioactive component. This review aims to compile the results of clinical, animal and cell culture studies evaluating the effects of HT on the features of Metabolic Syndrome (MetS) (body weight/adiposity, dyslipidemia, hypertension, and hyperglycemia/insulin resistance) and associated complications (oxidative stress and inflammation). HT was able to improve the lipid profile, glycaemia, and insulin sensitivity, and counteract oxidative and inflammatory processes. Experimental studies identified multiple molecular targets for HT conferring its beneficial effect on health in spite of its low bioavailability. However, rodent experiments and clinical trials with pure HT at biologically relevant concentrations are still lacking. Moreover, the roles of intestine and its gut microbiota have not been elucidated. View Full-Text
Keywords: olive oil; oleuropein; hydroxytyrosol; tyrosol; body weight; dyslipidemia; hyperglycemia; hypertension; oxidative stress; inflammation olive oil; oleuropein; hydroxytyrosol; tyrosol; body weight; dyslipidemia; hyperglycemia; hypertension; oxidative stress; inflammation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Peyrol, J.; Riva, C.; Amiot, M.J. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Nutrients 2017, 9, 306.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top