Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype
AbstractAntibody therapy remains the only effective treatment for toxin-mediated diseases. The development of hybridoma technology has allowed the isolation of monoclonal antibodies (mAbs) with high specificity and defined properties, and numerous mAbs have been purified and characterized for their protective efficacy against different toxins. This review summarizes the mAb studies for 6 toxins—Shiga toxin, pertussis toxin, anthrax toxin, ricin toxin, botulinum toxin, and Staphylococcal enterotoxin B (SEB)—and analyzes the prevalence of mAb functions and their isotypes. Here we show that most toxin-binding mAbs resulted from immunization are non-protective and that mAbs with potential therapeutic use are preferably characterized. Various common practices and caveats of protection studies are discussed, with the goal of providing insights for the design of future research on antibody-toxin interactions. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Chow, S.-K.; Casadevall, A. Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype. Toxins 2012, 4, 430-454.
Chow S-K, Casadevall A. Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype. Toxins. 2012; 4(6):430-454.Chicago/Turabian Style
Chow, Siu-Kei; Casadevall, Arturo. 2012. "Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype." Toxins 4, no. 6: 430-454.