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Toxins 2013, 5(2), 315-326; doi:10.3390/toxins5020315

Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis

1
Department of Ob/Gyn, Columbia University Medical Center, New York, NY 10032, USA
2
Department of Pharmacology, Columbia University Medical Center, New York, NY 10032, USA
3
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
4
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 January 2013 / Accepted: 31 January 2013 / Published: 6 February 2013
(This article belongs to the Special Issue Anthrax Toxin)
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Abstract

The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication.
Keywords: anthrax toxin receptors; MT1-MMP; extracellular matrix homeostasis; anthrax intoxication anthrax toxin receptors; MT1-MMP; extracellular matrix homeostasis; anthrax intoxication
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Reeves, C.; Charles-Horvath, P.; Kitajewski, J. Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis. Toxins 2013, 5, 315-326.

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