Next Article in Journal
Computational Design of Peptide Ligands for Ochratoxin A
Next Article in Special Issue
pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain
Previous Article in Journal
Determinants of pH-Dependent Modulation of Translocation in Dermonecrotic G-Protein-Deamidating Toxins
Previous Article in Special Issue
Insights into Diphthamide, Key Diphtheria Toxin Effector
Article Menu

Export Article

Open AccessReview
Toxins 2013, 5(6), 1180-1201; https://doi.org/10.3390/toxins5061180

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

Department of Medicine, Section of Hematology, Cancer Research & Cell Biology Laboratory, University of Verona, Verona, Italy
*
Author to whom correspondence should be addressed.
Received: 9 May 2013 / Revised: 5 June 2013 / Accepted: 13 June 2013 / Published: 18 June 2013
(This article belongs to the Special Issue Diphtheria Toxin)
View Full-Text   |   Download PDF [927 KB, uploaded 18 June 2013]   |  

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment. View Full-Text
Keywords: HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Vinante, F.; Rigo, A. Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis. Toxins 2013, 5, 1180-1201.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top