Next Article in Journal
Botulinum Toxin in Management of Limb Tremor
Previous Article in Journal
Awareness and Prevalence of Mycotoxin Contamination in Selected Nigerian Fermented Foods
Article Menu

Export Article

Open AccessReview
Toxins 2017, 9(11), 364; doi:10.3390/toxins9110364

Exolysin Shapes the Virulence of Pseudomonas aeruginosa Clonal Outliers

CNRS-ERL5261, INSERM, U1036, CEA, Bacterial Pathogenesis and Cellular Responses, Biosciences and Biotechnology Institute of Grenoble, University Grenoble Alpes, 17 rue des Martyrs, CEA-Grenoble, 38054 Grenoble, France
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Adam J. Ratner
Received: 13 October 2017 / Revised: 30 October 2017 / Accepted: 2 November 2017 / Published: 9 November 2017
(This article belongs to the Section Bacterial Toxins)
View Full-Text   |   Download PDF [1520 KB, uploaded 10 November 2017]   |  

Abstract

Bacterial toxins are important weapons of toxicogenic pathogens. Depending on their origin, structure and targets, they show diverse mechanisms of action and effects on eukaryotic cells. Exolysin is a secreted 170 kDa pore-forming toxin employed by clonal outliers of Pseudomonas aeruginosa providing to some strains a hyper-virulent behaviour. This group of strains lacks the major virulence factor used by classical strains, the Type III secretion system. Here, we review the structural features of the toxin, the mechanism of its secretion and the effects of the pore formation on eukaryotic cells. View Full-Text
Keywords: two-partner secretion; pore-forming toxin; type IV pili; cell junctions; ADAM10; inflammation; PA7-like strains; ExlA two-partner secretion; pore-forming toxin; type IV pili; cell junctions; ADAM10; inflammation; PA7-like strains; ExlA
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Reboud, E.; Basso, P.; Maillard, A.P.; Huber, P.; Attrée, I. Exolysin Shapes the Virulence of Pseudomonas aeruginosa Clonal Outliers. Toxins 2017, 9, 364.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top