Table of Contents
Toxins, Volume 9, Issue 12 (December 2017)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) Computer-aided design of the bioreceptor for ochratoxin monitoring: In solution, the unmodified [...] Read more. Computer-aided design of the bioreceptor for ochratoxin monitoring: In solution, the unmodified bioreceptor (blue) binds to ochratoxin (magenta) with its intrinsic affinity. However, on the biotransducer surface (cyan), the bioreceptor becomes sterically hindered. A hexa-histidine tag (His-tag ) (green) immobilizes the bioreceptor and recovers some of the configurational freedom. However, linking via the amine or acid end alters the mechanism of binding and the efficacy. The configurational freedom is improved by placing a polyethylene glycol (PEG) spacer (red) between the His-tag and bioreceptor. While experimental techniques are limited, computer-aided technologies are promising in a rationalized route to bioreceptor design. View this paper