Table of Contents
Toxins, Volume 9, Issue 3 (March 2017)
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Cover Story (view full-size image) BoNTs are diverse protein toxins. BoNT/HA is a newly identified mosaic toxin, while new toxin [...] Read more. BoNTs are diverse protein toxins. BoNT/HA is a newly identified mosaic toxin, while new toxin variants are being identified with increasing frequency. We present here the first crystal structure of the receptor-binding domain of BoNT/HA. Our structural analyses reveal that, even though BoNT/HA and the classical type A toxin (BoNT/A) have highly similar structures in this domain, BoNT/HA drastically dampens binding of a potent BoNT/A-neutralizing antibody targeting this domain via subtle genetic changes. View this paper