Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer
Abstract
:1. Introduction
2. Cell-Mediated Immune Response to Prostate Cancer
2.1. T Cells
2.2. NK and NKT Cells
3. Cell-Mediated Suppression of the Anti-Tumor Response
3.1. Regulatory T cells
3.2. Myeloid-Derived Suppressor Cells
3.3. Tumor-Associated Macrophages
4. Immunotherapy for Prostate Cancer
4.1. Sipuleucel-T (Provenge®)
4.2. PROSTVAC®-VF
4.3. Ipilimumab (Yervoy™)
5. Conclusions
Conflict of Interest
Acknowledgements
References
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Tucker, J.A.; Jochems, C.; Gulley, J.L.; Schlom, J.; Tsang, K.Y. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer. Cancers 2012, 4, 1333-1348. https://doi.org/10.3390/cancers4041333
Tucker JA, Jochems C, Gulley JL, Schlom J, Tsang KY. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer. Cancers. 2012; 4(4):1333-1348. https://doi.org/10.3390/cancers4041333
Chicago/Turabian StyleTucker, Jo A., Caroline Jochems, James L. Gulley, Jeffrey Schlom, and Kwong Y. Tsang. 2012. "Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer" Cancers 4, no. 4: 1333-1348. https://doi.org/10.3390/cancers4041333