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Cancers 2017, 9(4), 34; doi:10.3390/cancers9040034

AR Signaling and the PI3K Pathway in Prostate Cancer

1
Kinghorn Cancer Centre, St Vincent’s Hospital, 370 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
2
Garvan Institute of Medical Research, St Vincent’s Clinical School, University of New South Wales, Sydney, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
3
AstraZeneca UK, Clinical Discovery Unit, Early Clinical Development Innovative Medicines, da Vinci Building, Melbourn Science Park, Melbourn, Hertfordshire SG8 6HB, UK
4
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust Cambridge Biomedical Campus, Hills Rd, Cambridge CB2 0QQ, UK
5
Princess Margaret Cancer Centre, University Health Network, University of Toronto, University Avenue, Toronto, ON M5G 2M9, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel S. Antonarakis
Received: 27 February 2017 / Revised: 4 April 2017 / Accepted: 11 April 2017 / Published: 15 April 2017
(This article belongs to the Special Issue AR Signaling in Human Malignancies: Prostate Cancer and Beyond)
View Full-Text   |   Download PDF [399 KB, uploaded 19 April 2017]   |  

Abstract

Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is critical in the development and progression of prostate cancer. Despite ongoing reliance on androgen receptor (AR) signaling in castrate resistant disease, in addition to the development of potent androgen targeting drugs, patients invariably develop treatment resistance. Interactions between the AR and PI3K pathways may be a mechanism of treatment resistance and inhibitors of this pathway have been developed with variable success. Herein we outline the role of the PI3K pathway in prostate cancer and, in particular, its association with androgen receptor signaling in the pathogenesis and evolution of prostate cancer, as well as a review of the clinical utility of PI3K targeting. View Full-Text
Keywords: PI3K; prostate cancer; AR signaling; castrate resistant prostate cancer PI3K; prostate cancer; AR signaling; castrate resistant prostate cancer
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Crumbaker, M.; Khoja, L.; Joshua, A.M. AR Signaling and the PI3K Pathway in Prostate Cancer. Cancers 2017, 9, 34.

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