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Cancers 2017, 9(4), 36; doi:10.3390/cancers9040036

Cancer Chemotherapy Specific to Acidic Nests

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan
Academic Editor: Samuel Mok
Received: 19 March 2017 / Revised: 17 April 2017 / Accepted: 18 April 2017 / Published: 20 April 2017
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Abstract

The realization of cancer therapeutics specific to cancer cells with less of an effect on normal tissues is our goal. Many trials have been carried out for this purpose, but this goal is still far from being realized. It was found more than 80 years ago that solid cancer nests are acidified, but in vitro studies under acidic conditions have not been extensively studied. Recently, in vitro experiments under acidic conditions were started and anti-cancer drugs specific to acidic areas have been identified. Many genes have been reported to be expressed at a high level under acidic conditions, and such genes may be potent targets for anti-cancer drugs specific to acidic nests. In this review article, recent in vitro, in vivo, and clinical achievements in anti-cancer drugs with marked efficacy under acidic conditions are summarized, and the clinical use of anti-cancer drugs specific to acidic nests is discussed. View Full-Text
Keywords: chemotherapy; acidosis of cancer nests; statins; cantharidin; manumycin A; ionomycin; acidosis-dependent gene expression chemotherapy; acidosis of cancer nests; statins; cantharidin; manumycin A; ionomycin; acidosis-dependent gene expression
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kobayashi, H. Cancer Chemotherapy Specific to Acidic Nests. Cancers 2017, 9, 36.

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