Table of Contents
Catalysts, Volume 8, Issue 3 (March 2018)
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Cover Story (view full-size image) Sabine Berteina-Raboin’s team has developed an efficient total synthesis of abscisic acid (ABA) and [...] Read more. Sabine Berteina-Raboin’s team has developed an efficient total synthesis of abscisic acid (ABA) and some analogues. The construction of these compounds was achieved through a series of reactions involving a solvent-free Mizoroki-Heck reaction. ABA is a natural product (phytohormone) that has recently exhibit interesting biological activities in blood sugar regulation, emphasizing the need for simple and direct access to new analogues based on the ABA framework. The strategy relied on a palladium catalyzed Heck cross-coupling as key reaction performed under solvent and ligand-free conditions. After a careful optimization, the team succeeded to access various (E/Z)-dienes and (E/E/Z)-trienes in moderate to good yields without racemization and applied the same approach to the synthesis of the ABA in an environmentally sound manner. View the paper here.