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Cells 2013, 2(2), 393-413; doi:10.3390/cells2020393

Systems Biology: The Role of Engineering in the Reverse Engineering of Biological Signaling

Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
Received: 4 April 2013 / Revised: 6 May 2013 / Accepted: 15 May 2013 / Published: 31 May 2013
(This article belongs to the Special Issue Successes of Systems Biology and Future Challenges)
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Abstract

One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells. View Full-Text
Keywords: control engineering; information theory; signal processing; statistical inference; homeostasis control engineering; information theory; signal processing; statistical inference; homeostasis
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Iglesias, P.A. Systems Biology: The Role of Engineering in the Reverse Engineering of Biological Signaling. Cells 2013, 2, 393-413.

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