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Cells 2013, 2(4), 732-750; doi:10.3390/cells2040732

Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles

Department of Biological Sciences, Tokyo Institute of Technology, 4259-B13 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
Received: 7 October 2013 / Revised: 12 November 2013 / Accepted: 29 November 2013 / Published: 5 December 2013
(This article belongs to the Special Issue Protein Ubiquitination)
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Abstract

It is now understood that protein ubiquitination has diverse cellular functions in eukaryotes. The molecular mechanism and physiological significance of ubiquitin-mediated processes have been extensively studied in yeast, Drosophila and mammalian somatic cells. Moreover, an increasing number of studies have emphasized the importance of ubiquitination in spermatogenesis and fertilization. The dysfunction of various ubiquitin systems results in impaired sperm development with abnormal organelle morphology and function, which in turn is highly associated with male infertility. This review will focus on the emerging roles of ubiquitination in biogenesis, function and stability of sperm organelles in mammals. View Full-Text
Keywords: acrosome; deubiquitination; histone; membrane trafficking; mitochondria; mitophagy; spermatogenesis; spermiogenesis; ubiquitination acrosome; deubiquitination; histone; membrane trafficking; mitochondria; mitophagy; spermatogenesis; spermiogenesis; ubiquitination
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nakamura, N. Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles. Cells 2013, 2, 732-750.

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