Table of Contents
Cells, Volume 7, Issue 6 (June 2018)
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Cover Story (view full-size image) Single cell analysis provides an approach to directly link external stimulation of an individual [...] Read more. Single cell analysis provides an approach to directly link external stimulation of an individual cell to molecular changes in that same cell. Nanopipette technology can provide multiplexed, single cell analysis over time. The core technology employs a nanopipette instrument, which is a hollow quartz needle with a tip opening of less than 100 nm. By employing scanning ion conductance microscopy, changes in ion current through the nanopipette tip can be used to find cell surfaces using a proximity effect known as “current squeezing”, which Pourmand’s team have previously described. View the paper here.