Lessons from Genome-Wide Search for Disease-Related Genes with Special Reference to HLA-Disease Associations
AbstractThe relationships between diseases and genetic factors are by no means uniform. Single-gene diseases are caused primarily by rare mutations of specific genes. Although each single-gene disease has a low prevalence, there are an estimated 5000 or more such diseases in the world. In contrast, multifactorial diseases are diseases in which both genetic and environmental factors are involved in onset. These include a variety of diseases, such as diabetes and autoimmune diseases, and onset is caused by a range of various environmental factors together with a number of genetic factors. With the astonishing advances in genome analysis technology in recent years and the accumulation of data on human genome variation, there has been a rapid progress in research involving genome-wide searches for genes related to diseases. Many of these studies have led to the recognition of the importance of the human leucocyte antigen (HLA) gene complex. Here, the current state and future challenges of genome-wide exploratory research into variations that are associated with disease susceptibilities and drug/therapy responses are described, mainly with reference to our own experience in this field. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Tokunaga, K. Lessons from Genome-Wide Search for Disease-Related Genes with Special Reference to HLA-Disease Associations. Genes 2014, 5, 84-96.
Tokunaga K. Lessons from Genome-Wide Search for Disease-Related Genes with Special Reference to HLA-Disease Associations. Genes. 2014; 5(1):84-96.Chicago/Turabian Style
Tokunaga, Katsushi. 2014. "Lessons from Genome-Wide Search for Disease-Related Genes with Special Reference to HLA-Disease Associations." Genes 5, no. 1: 84-96.