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Genes 2017, 8(11), 321; doi:10.3390/genes8110321

Comprehensive Profiling of lincRNAs in Lung Adenocarcinoma of Never Smokers Reveals Their Roles in Cancer Development and Prognosis

1
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Pulmonary Medicine, People’s Hospital of Henan Province, Zhengzhou 450003, China
*
Authors to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 28 October 2017 / Accepted: 6 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Integrative Genomics and Systems Medicine in Cancer)
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Abstract

Long intergenic non-coding RNA (lincRNA) is a family of gene transcripts, the functions of which are largely unknown. Although cigarette smoking is the main cause for lung cancer, lung cancer in non-smokers is a separate entity and its underlying cause is little known. Growing evidence suggests lincRNAs play a significant role in cancer development and progression; however, such data is lacking for lung cancer in non-smokers, or those who have never smoked. This study conducted comprehensive profiling of lincRNAs from RNA sequencing (RNA-seq) data of non-smoker patients with lung adenocarcinoma. Both known and novel lincRNAs distinctly segregated tumors from normal tissues. Approximately one third of lincRNAs were differentially expressed between tumors and normal samples and most of them were coordinated with their putative protein gene targets. More importantly, lincRNAs defined two clusters of tumors that were associated with tumor aggressiveness and patient survival. We identified a subset of lincRNAs that were differentially expressed and also associated with patient survival. Very high concordance (R2 = 0.9) was observed for the differentially expressed lincRNAs in the Cancer Genome Atlas (TCGA) validation set of 85 transcriptomes and the lincRNAs associated with survival from the discovery set were similarly predictive in the validation set. These lincRNAs warrant further investigation as potential diagnostic and prognostic markers. View Full-Text
Keywords: long intergenic non-coding RNA; never smokers; lung adenocarcinoma; RNA-sequencing long intergenic non-coding RNA; never smokers; lung adenocarcinoma; RNA-sequencing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, Y.; Wang, Z.; Nair, A.; Song, W.; Yang, P.; Zhang, X.; Sun, Z. Comprehensive Profiling of lincRNAs in Lung Adenocarcinoma of Never Smokers Reveals Their Roles in Cancer Development and Prognosis. Genes 2017, 8, 321.

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