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Genes 2017, 8(3), 92; doi:10.3390/genes8030092

The Role of the Transcriptional Response to DNA Replication Stress

1
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
2
The UCL Cancer Institute, University College London, London WC1E 6BT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Eishi Noguchi
Received: 20 January 2017 / Revised: 20 February 2017 / Accepted: 23 February 2017 / Published: 2 March 2017
(This article belongs to the Special Issue DNA Replication Controls)
View Full-Text   |   Download PDF [988 KB, uploaded 2 March 2017]   |  

Abstract

During DNA replication many factors can result in DNA replication stress. The DNA replication stress checkpoint prevents the accumulation of replication stress-induced DNA damage and the potential ensuing genome instability. A critical role for post-translational modifications, such as phosphorylation, in the replication stress checkpoint response has been well established. However, recent work has revealed an important role for transcription in the cellular response to DNA replication stress. In this review, we will provide an overview of current knowledge of the cellular response to DNA replication stress with a specific focus on the DNA replication stress checkpoint transcriptional response and its role in the prevention of replication stress-induced DNA damage. View Full-Text
Keywords: DNA replication; DNA replication stress; checkpoint response; Chk1; E2F-dependent transcription; E2F6; oncogene-induced replication stress DNA replication; DNA replication stress; checkpoint response; Chk1; E2F-dependent transcription; E2F6; oncogene-induced replication stress
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Herlihy, A.E.; de Bruin, R.A. The Role of the Transcriptional Response to DNA Replication Stress. Genes 2017, 8, 92.

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