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Symmetry 2014, 6(3), 704-721; doi:10.3390/sym6030704

Adhesive/Repulsive Codes in Vertebrate Forebrain Morphogenesis

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Nicolás Cabrera 1, Madrid 28049, Spain
Received: 29 June 2014 / Revised: 29 July 2014 / Accepted: 4 August 2014 / Published: 14 August 2014
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The last fifteen years have seen the identification of some of the mechanisms involved in anterior neural plate specification, patterning, and morphogenesis, which constitute the first stages in the formation of the forebrain. These studies have provided us with a glimpse into the molecular mechanisms that drive the development of an embryonic structure, and have resulted in the realization that cell segregation in the anterior neural plate is essential for the accurate progression of forebrain morphogenesis. This review summarizes the latest advances in our understanding of mechanisms of cell segregation during forebrain development, with and emphasis on the impact of this process on the morphogenesis of one of the anterior neural plate derivatives, the eyes.
Keywords: anterior neural plate; eye field; cell segregation; cadherins; Ephrins anterior neural plate; eye field; cell segregation; cadherins; Ephrins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cavodeassi, F. Adhesive/Repulsive Codes in Vertebrate Forebrain Morphogenesis. Symmetry 2014, 6, 704-721.

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