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Symmetry 2017, 9(5), 74; doi:10.3390/sym9050074

Coupling Form and Function: How the Oligomerisation Symmetry of the SAS-6 Protein Contributes to the Architecture of Centriole Organelles

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
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Academic Editor: John H. Graham
Received: 9 April 2017 / Revised: 6 May 2017 / Accepted: 12 May 2017 / Published: 16 May 2017
(This article belongs to the Special Issue Symmetry in Structural Biology)
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Abstract

Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it forms the central core of the organelle, which is then surrounded by microtubules. SAS-6 self-assembles into an oligomer with elongated spokes that emanate towards the outer microtubule wall; in this manner, the symmetry of the SAS-6 oligomer influences centriole architecture and symmetry. Here, we summarise the form and symmetry of SAS-6 oligomers inferred from crystal structures and directly observed in vitro. We discuss how the strict 9-fold symmetry of centrioles may emerge, and how different forms of SAS-6 oligomers may be accommodated in the organelle architecture. View Full-Text
Keywords: centriole; oligomer symmetry; SAS-6; spiral; cartwheel centriole; oligomer symmetry; SAS-6; spiral; cartwheel
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Ford, J.E.; Stansfeld, P.J.; Vakonakis, I. Coupling Form and Function: How the Oligomerisation Symmetry of the SAS-6 Protein Contributes to the Architecture of Centriole Organelles. Symmetry 2017, 9, 74.

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