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Symmetry 2017, 9(8), 150; doi:10.3390/sym9080150

Gate Antiphase of Potassium Channel

Projects and Physics Section, Sapir Academic College, D.N. Hof Ashkelon 79165, Israel
Received: 19 June 2017 / Revised: 5 August 2017 / Accepted: 6 August 2017 / Published: 8 August 2017
(This article belongs to the Special Issue Symmetry in Structural Biology)
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Abstract

Potassium channels are integral membrane proteins that selectively transport K+ ions across cell membranes. They function through a pair of gates, which work in tandem to allow the passage of the ions through the channel pore in a coupled system, to which I refer to here as the “gate linker”. The functional mutation effects, as described in the literature, suggest that the gate linker functions analogously to a triad of coiled springs arranged in series. Accordingly, I constructed a physical model of harmonic oscillators and analyzed it mechanically and mathematically. The operation of this model indeed corresponds to the phenomena observed in the mutations study. The harmonic oscillator model shows that the strength of the gate linker is crucial for gate coupling and may account for the velocity, direction, and efficiency of ion transfer through the channel. Such a physical perspective of the gating process suggests new lines of investigation regarding the coupling mode of potassium channels and may help to explain the importance of the gate linker to channel function. View Full-Text
Keywords: potassium channels; gate linker; harmonic oscillator; coupling potassium channels; gate linker; harmonic oscillator; coupling
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Ben-Abu, Y. Gate Antiphase of Potassium Channel. Symmetry 2017, 9, 150.

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