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Behav. Sci. 2013, 3(2), 206-216; doi:10.3390/bs3020206
Article

Facilitation of Relational Learning in Schizophrenia

1
,
1
,
2
,
1,3
 and
1,4,*
1 Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA 2 Department of Psychology, University of Connecticut Waterbury, 99 East Main Street Waterbury, CT 06702, USA 3 Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA 4 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA
* Author to whom correspondence should be addressed.
Received: 15 February 2013 / Revised: 25 March 2013 / Accepted: 26 March 2013 / Published: 12 April 2013
(This article belongs to the Special Issue Learning and Memory Deficits Related to Neuropsychiatric Disorders)
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Abstract

Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training.
Keywords: schizophrenia; relational learning; training; transverse patterning; hippocampus; medial temporal lobe; memory schizophrenia; relational learning; training; transverse patterning; hippocampus; medial temporal lobe; memory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Spieker, E.A.; Griego, J.A.; Astur, R.S.; Holcomb, H.H.; Rowland, L.M. Facilitation of Relational Learning in Schizophrenia. Behav. Sci. 2013, 3, 206-216.

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