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Behav. Sci. 2013, 3(2), 298-315; doi:10.3390/bs3020298

Hippocampal Physiology, Structure and Function and the Neuroscience of Schizophrenia: A Unified Account of Declarative Memory Deficits, Working Memory Deficits and Schizophrenic Symptoms

Harvard Medical School, VA Boston Healthcare System, 940 Belmont Street Psychiatry 116A Brockton, MA 02301, USA
Received: 25 April 2013 / Revised: 30 May 2013 / Accepted: 8 June 2013 / Published: 21 June 2013
(This article belongs to the Special Issue Learning and Memory Deficits Related to Neuropsychiatric Disorders)
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Abstract

Memory impairment is a consistent feature of the schizophrenic syndrome. Hippocampal dysfunction has also been consistently demonstrated. This review will discuss neurophysiological and neuroanatomical aspects of memory formation and how they relate to memory impairment in schizophrenia. An understanding of the cellular physiology and connectivity of the hippocampus with other regions can also aid in understanding the relationship between schizophrenic declarative or relational memory deficits, working memory deficits and the clinical symptoms of the syndrome. View Full-Text
Keywords: hippocampus; memory; schizophrenia; parietal; superior temporal sulcus; social cognition hippocampus; memory; schizophrenia; parietal; superior temporal sulcus; social cognition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wible, C.G. Hippocampal Physiology, Structure and Function and the Neuroscience of Schizophrenia: A Unified Account of Declarative Memory Deficits, Working Memory Deficits and Schizophrenic Symptoms. Behav. Sci. 2013, 3, 298-315.

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