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Appl. Sci. 2017, 7(3), 288; doi:10.3390/app7030288

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

Department of Communications Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan
Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan
Author to whom correspondence should be addressed.
Academic Editor: Kohji Masuda
Received: 28 October 2016 / Revised: 22 February 2017 / Accepted: 3 March 2017 / Published: 16 March 2017
(This article belongs to the Special Issue Biomedical Ultrasound)
View Full-Text   |   Download PDF [10684 KB, uploaded 16 March 2017]   |  


A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named “trigger HIFU exposure” which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency. View Full-Text
Keywords: HIFU; focused ultrasound; cavitation; microbubble; ultrasound imaging HIFU; focused ultrasound; cavitation; microbubble; ultrasound imaging

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yoshizawa, S.; Takagi, R.; Umemura, S.-I. Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation. Appl. Sci. 2017, 7, 288.

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