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Appl. Sci. 2017, 7(3), 306; doi:10.3390/app7030306

Influence of Hard Segments on the Thermal, Phase-Separated Morphology, Mechanical, and Biological Properties of Polycarbonate Urethanes

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China
School of Foreign Languages, Wuhan University of Technology, Wuhan 430070, China
Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Author to whom correspondence should be addressed.
Academic Editors: Daniel X.B. Chen and Hidenori Otsuka
Received: 9 December 2016 / Revised: 23 February 2017 / Accepted: 16 March 2017 / Published: 20 March 2017
View Full-Text   |   Download PDF [3286 KB, uploaded 22 March 2017]   |  


Abstract: In this study, we have fabricated a series of polycarbonate polyurethanes using a two-step bulk reaction by the melting pre-polymer solution-casting method in order to synthesize biomedical polyurethane elastomers with good mechanical behavior and biostability. The polyurethanes were prepared using dibutyltin dilaurate as the catalyst, poly(1,6-hexanediol)carbonate microdiols (PCDL) as the soft segment, and the chain extender 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) as the hard segments. The chemical structures and physical properties of the obtained films were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, gel permeation chromatography (GPC), differential scanning calorimeter (DSC), and mechanical property tests. The surface properties and degrees of microphase separation were further analyzed by water droplet contact angle measurements (CA) and atomic force microscopy (AFM). The materials exhibited a moderate toxic effect on the tetrazolium (MTT) assay and good hemocompatibility through hemolytic tests, indicating a good biocompatibility of the fabricated membranes. The materials could be considered as potential and beneficial suitable materials for tissue engineering, especially in the fields of artificial blood-contacting implants or other biomedical applications. View Full-Text
Keywords: polyurethanes; hard segment; mechanical behavior; biocompatibility polyurethanes; hard segment; mechanical behavior; biocompatibility

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, R.; Wang, X.; Yang, J.; Wang, Y.; Zhang, Z.; Hou, Y.; Lin, F.; Li, Y. Influence of Hard Segments on the Thermal, Phase-Separated Morphology, Mechanical, and Biological Properties of Polycarbonate Urethanes. Appl. Sci. 2017, 7, 306.

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