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Brain Sci. 2013, 3(1), 344-359; doi:10.3390/brainsci3010344

The Role of Ghrelin in Neuroprotection after Ischemic Brain Injury

School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Melbourne, VIC 3083, Australia
Department of Pharmacology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia
Department of Physiology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia
Author to whom correspondence should be addressed.
Received: 10 December 2012 / Revised: 19 February 2013 / Accepted: 7 March 2013 / Published: 19 March 2013
(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
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Ghrelin, a gastrointestinal peptide with a major role in regulating feeding and metabolism, has recently been investigated for its neuroprotective effects. In this review we discuss pre-clinical evidence suggesting ghrelin may be a useful therapeutic in protecting the brain against injury after ischemic stroke. Specifically, we will discuss evidence showing ghrelin administration can improve neuronal cell survival in animal models of focal cerebral ischemia, as well as rescue memory deficits. We will also discuss its proposed mechanisms of action, including anti-apoptotic and anti-inflammatory effects, and suggest ghrelin treatment may be a useful intervention after stroke in the clinic.
Keywords: ghrelin; neurodegeneration; apoptosis; inflammation ghrelin; neurodegeneration; apoptosis; inflammation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Spencer, S.J.; Miller, A.A.; Andrews, Z.B. The Role of Ghrelin in Neuroprotection after Ischemic Brain Injury. Brain Sci. 2013, 3, 344-359.

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