Next Article in Journal
Recent Developments in Preclinical DNA Vaccination
Next Article in Special Issue
Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention
Previous Article in Journal
Pilot Study on the Use of DNA Priming Immunization to Enhance Y. pestis LcrV-Specific B Cell Responses Elicited by a Recombinant LcrV Protein Vaccine
Article Menu

Export Article

Open AccessReview
Vaccines 2014, 2(1), 49-88; doi:10.3390/vaccines2010049

Development of Streptococcus pneumoniae Vaccines Using Live Vectors

1
Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
2
School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
*
Author to whom correspondence should be addressed.
Received: 11 October 2013 / Revised: 9 November 2013 / Accepted: 27 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Pneumococcal Vaccine in the 21st Century)
View Full-Text   |   Download PDF [766 KB, 8 January 2014; original version 7 January 2014]

Abstract

Streptococcus pneumoniae still causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular vaccines and capsular conjugate vaccines, such as serotype replacement, limited coverage and high costs. A recombinant live vector vaccine delivering protective antigens is a promising way to achieve this goal. In this review, we discuss the researches using live recombinant vaccines, mainly live attenuated Salmonella and lactic acid bacteria, to deliver pneumococcal antigens. We also discuss both the limitations and the future of these vaccines. View Full-Text
Keywords: Streptococcus pneumoniae; Salmonella; lactic acid bacteria; BCG; adenoviruses; bacterial vector; viral vector Streptococcus pneumoniae; Salmonella; lactic acid bacteria; BCG; adenoviruses; bacterial vector; viral vector
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, S.; Curtiss III, R. Development of Streptococcus pneumoniae Vaccines Using Live Vectors. Vaccines 2014, 2, 49-88.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top