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J. Funct. Biomater. 2012, 3(3), 528-543; doi:10.3390/jfb3030528

Surface Treatment of Polymeric Materials Controlling the Adhesion of Biomolecules

1,* , 1,2
1 Département Polymères, Institut des Molécules et Matériaux du Mans, LUNAM Université, UMR Université du Maine—CNRS No. 6283, Colloïdes et Interfaces, Avenue Olivier Messiaen Le Mans Cedex 72085, France 2 Jozef Stefan Institute, Jamova cesta 39, Ljubljana 1000, Slovenia 3 CTTM, 20 rue Thalès de Milet, Le Mans 72000, France 4 Centre de Recherche sur les Protéines Prion, Institut de Pharmacie, B36, No. 1 avenue de l’Hôpital, Liège 4000, Belgium
* Author to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 25 July 2012 / Accepted: 26 July 2012 / Published: 7 August 2012
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This review describes different strategies of surface elaboration for a better control of biomolecule adsorption. After a brief description of the fundamental interactions between surfaces and biomolecules, various routes of surface elaboration are presented dealing with the attachment of functional groups mostly thanks to plasma techniques, with the grafting to and from methods, and with the adsorption of surfactants. The grafting of stimuli-responsive polymers is also pointed out. Then, the discussion is focused on the protein adsorption phenomena showing how their interactions with solid surfaces are complex. The adsorption mechanism is proved to be dependent on the solid surface physicochemical properties as well as on the surface and conformation properties of the proteins. Different behaviors are also reported for complex multiple protein solutions.
Keywords: surface; polymer; modification; bioadhesion; biomolecules surface; polymer; modification; bioadhesion; biomolecules
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Poncin-Epaillard, F.; Vrlinic, T.; Debarnot, D.; Mozetic, M.; Coudreuse, A.; Legeay, G.; El Moualij, B.; Zorzi, W. Surface Treatment of Polymeric Materials Controlling the Adhesion of Biomolecules. J. Funct. Biomater. 2012, 3, 528-543.

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