Next Article in Journal
Non-Metallic Biomaterials for Tooth Repair and Replacement. By Pekka Vallittu, Woodhead Publishing, 2013; 406 pages. Price £145.00/US$245.00/€175.00 ISBN 978-0-85709-244-1
Previous Article in Journal
Biocompatibility of Bacterial Cellulose Based Biomaterials
Previous Article in Special Issue
Novel in Vitro Model for Keratoconus Disease
Article Menu

Export Article

Open AccessReview
J. Funct. Biomater. 2012, 3(4), 879-894; doi:10.3390/jfb3040879

Extracellular Matrix is an Important Component of Limbal Stem Cell Niche

Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095, USA
This authors contributed equally.
*
Author to whom correspondence should be addressed.
Received: 7 September 2012 / Revised: 4 December 2012 / Accepted: 5 December 2012 / Published: 10 December 2012
(This article belongs to the Special Issue Corneal Scarring: Wound Healing and Biomaterials)
View Full-Text   |   Download PDF [241 KB, uploaded 11 December 2012]

Abstract

Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data suggest that these components are part of the stem cell niche and play a role in the homeostasis of limbal stem cells. The extracellular matrix provides a mechanical and structural support as well as regulates cellular functions such as adhesion, migration, proliferation, self-renewal and differentiation. Optimization of the extracellular matrix components might be able to recreate an ex vivo stem cell niche to expand limbal stem cells.
Keywords: extracellular matrix; stem cell niche; limbal stem cell; limbus extracellular matrix; stem cell niche; limbal stem cell; limbus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mei, H.; Gonzalez, S.; Deng, S.X. Extracellular Matrix is an Important Component of Limbal Stem Cell Niche. J. Funct. Biomater. 2012, 3, 879-894.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top